CORDIS Project
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This project investigates the molecular mechanisms behind the gliding motility of malaria parasites, specifically focusing on the ookinete stage. By analyzing calcium and cGMP-dependent signaling pathways, the research aims to identify key molecular targets that influence the motility of Plasmodium berghei, enhancing o…
Malaria parasites critically depend on an unusual form of gliding motility to colonize their hosts and to invade cells.
Transmission of malaria to the mosquito, for instance, relies on the ability of the motile zygote, the ookinete, to glide towards and invade the midgut epithelium.
Results obtained in the host team have revealed a central role of cGMP- and calcium-dependent signalling in ookinete motility.
Nevertheless, how these pathways control gliding is unknown. I therefore propose to combi…
GENOME RESEARCH LIMITED
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