CORDIS Project
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This research investigates the mechanisms of nucleosome retention in mouse sperm, focusing on how environmental factors influence epigenetic inheritance. By analyzing histone variants and modifications, the project aims to uncover the biological processes that affect offspring development across generations.
Studies in mice and men suggest that changes in environmental conditions such as nutrition, exposure to environmental pollutants or parental care during early postnatal life can affect the development, physiology and fitness of offspring.
The epigenetic mechanisms underlying the transmission of such traits over one or multiple generations are largely unknown but DNA methylation, RNA and nucleosomes have been proposed as mediators of such inheritance.
At the end of male germ cell development chro…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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