CORDIS Project
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This project explores how cytomegalovirus affects T cell responses during infection. It aims to understand the immune evasion mechanisms of the virus and their implications for developing effective vaccination strategies.
Cytomegalovirus (CMV, a β-herpesvirus) infects the majority of the world’s population, establishing a lifelong infection.
This infection is largely asymptomatic in immune competent hosts, but causes severe disease in immunocompromised neonates and adults.
In healthy persistently infected individuals huge numbers of CMV-specific T cells accumulate over time (i.e. “memory inflation”), a process recently associated with the immune risk profile and immune senescence in the elderly. CMV encodes numer…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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