CORDIS Project
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This project investigates the role of Polycomb group proteins in maintaining cellular identity during development and differentiation. It aims to dissect the contributions of different Polycomb complexes to gene expression and chromatin profiles in stem cells and adult tissues.
The activities of the Polycomb group (PcG) of repressive chromatin modifiers are required to maintain correct transcriptional identity during development and differentiation.
These activities are altered in a variety of tumours by gain- or loss-of-function mutations, whose mechanistic aspects still remain unclear.PcGs can be classified in two major repressive complexes (PRC1 and PRC2) with common pathways but distinct biochemical activities. PRC1 catalyses histone H2A ubiquitination of lysine 11…
UNIVERSITA DEGLI STUDI DI MILANO
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ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy, Milano
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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