CORDIS Project
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The DISTINCT project investigates how the Salmonella Typhimurium strain ST313 infects human cells, particularly in vulnerable populations in sub-Saharan Africa. By using advanced genome analysis techniques, it aims to identify specific genes that enable this pathogen to survive in human immune cells, potentially leadin…
Salmonella enterica serovar Typhimurium infects a wide range of animal hosts and normally causes a self-limiting gastroenteritis in humans.
However, new variants of this serovar known as ST313 have emerged as important pathogens in sub-Saharan Africa, causing an invasive disease in susceptible HIV+ or malarial individuals.
Genome sequencing showed that the ST313 isolate D23580 is closely related to other nontyphoidal Salmonella.
For example, D23580 shares 94% of coding genes with the well-charac…
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