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The DIVA project focuses on developing novel variants of avidin proteins through genetic engineering and the exploration of new avidin sequences. This aims to enhance their applications in biotechnology, including diagnostics, drug delivery, and nanotechnology.
Avidins are amongst the most widely used proteins in biotechnology, with applications encompassing molecular labelling, purification & detection, as well as uses in diagnostics, targeted drug delivery and nanotechnology, such as enantioselective catalysis by artificial catalysts.
Avidins also serve as outstanding model systems for our understanding of biomolecular interactions, through their extremely high affinity for biotin (dissociation constant, Kd≈10−14–10−16 M).and biotinylated molecules.…
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