CORDIS Project
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This project studies the mechanisms by which the bacterium Shigella invades human intestinal cells. It focuses on the role of a specialized secretion system that manipulates host cell signaling to facilitate bacterial entry, particularly in polarized epithelial cells.
Shigella is a gram-negative enteropathogenic bacterium responsible for dysentery in humans.
The type III secretion system (T3SS) encoded on a large plasmid is a key virulence factor of Shigella.
Upon epithelial contact, the T3SS allows the translocation of effector proteins into the target cells subverting host cell signal transduction pathways.
These T3SS effectors reorganize the actin cytoskeleton through the targeting of RhoGTPases and tyrosine kinase signaling, leading to localized membrane…
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