CORDIS Project
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This project focuses on understanding how T cell development is influenced by specific peptide complexes and antigen processing pathways. By integrating proteomics with in vivo studies, it aims to uncover mechanisms that could lead to new vaccines and therapies for immune-related disorders.
Impaired selection of a functional and self-tolerant T cell repertoire is an underlying cause for development of immune system related disorders: immune-deficiencies and autoimmunity.
However, current knowledge fails to explain how seemingly the same self-MHC/peptide complexes mediate the processes with completely different outcomes: survival versus apoptosis of T cells.
In line, the nature of MHC/peptide complexes that mediate development of immune system and the influence of different antigen…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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