CORDIS Project
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This project focuses on discovering new antibacterial molecules through innovative organic and medicinal chemistry techniques. It aims to develop diverse small cyclic peptides and optimize solid phase organic synthesis methods, followed by biological screening against human pathogens to identify effective compounds.
Our aim is to find new antibacterial molecules with novel mechanisms of action, by applying new and innovative approaches in organic and medicinal chemistry, such as diversity-oriented synthesis (DOS) and chemical genetics.
The concrete objectives are: -Development of diversity-oriented synthesis (DOS) using solid phase and solution synthesis to obtain collections of highly diverse and complex small cyclic peptide derivatives including small cyclic di- tri- and tetra- peptides as well as bicycli…
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