CORDIS Project
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This project focuses on improving gene therapy for cancer treatment by engineering homing endonucleases, specifically the I-DmoI enzyme. It aims to enhance the specificity and safety of gene editing techniques, particularly for skin cancer, by understanding the mechanisms of DNA cleavage and repair.
An important aspect of cancer therapy is the specificity of the treatment.
Significant progress has been made in drug design.
However, gene therapy by direct targeting of oncogenes has not yet met equal success.
Among the most valuable tools are meganucleases, also known as homing endonucleases (HE).
These enzymes recognize and cleave long (around 20bp) DNA sequences and have been shown to induce gene repair in vivo efficiently.
The mechanism involves induction of homologous recombination (HR) b…
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