CORDIS Project
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This research focuses on understanding how bulky DNA adducts from dietary carcinogens contribute to cancer risk. By developing synthetic nucleosides as diagnostic tools, the project aims to study the formation and repair of DNA damage linked to dietary exposures.
Bulky DNA adducts formed from chemical carcinogens dictate structure, reactivity, and mechanism of chemical-biological reactions; therefore, their identification is central to evaluating and mitigating cancer risk.
Natural food components, or others associated with certain food preparations or metabolic conversions, initiate potentially damaging genetic mutations after forming DNA adducts, which contribute critically to carcinogenesis, despite the fact that they are typically repaired biochemic…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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