CORDIS Project
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This project aims to investigate the structure and function of a protein complex involved in mitochondrial architecture using DNA origami scaffolds. By mimicking mitochondrial compartments, it seeks to understand how this complex regulates the transport of molecules within mitochondria, contributing to our knowledge of…
Mitochondrial cristae are functional dynamic compartments containing the respiratory chain complexes where oxidative phosphorylation occurs.
They are separated from the inner boundary membrane by highly curved and tightly regulated membrane compartments called crista junctions (CJs). A key multi-protein complex, mitochondrial contact site and cristae organizing system (MICOS), is enriched in CJs and plays a central role in modulating the architecture and function of CJs.
Recently, a MICOS subcom…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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