CORDIS Project
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This project investigates the mechanisms of DNA replication by using advanced imaging techniques to visualize entire replication reactions in vitro. By combining cryo-electron microscopy with biochemical methods, it aims to reveal how protein structures influence DNA replication processes, which are crucial for underst…
Genome duplication is essential for cell proliferation.
Errors in the mechanisms that control DNA replication can cause genomic instability and lead to the development of genetic diseases and cancer.
In vitro reconstitution of DNA replication with purified yeast proteins has helped uncover important mechanisms of DNA replication.
How changes in protein structure regulates function during key events in origin activation and replisome progression, such as melting of the DNA duplex upon CMG helicas…
THE FRANCIS CRICK INSTITUTE LIMITED
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