CORDIS Project
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This project investigates how cells sense and repair DNA damage during replication. By studying single-stranded DNA gaps and their role in checkpoint activation, it aims to enhance understanding of DNA repair mechanisms and their implications for human health.
The genetic information encoded by DNA is under constant attack from both endogenous and exogenous sources of damage.
To ensure genome stability and prevent disease, cells use global signaling networks to sense and repair DNA damage.
One particularly serious problem is when the replication machinery encounters lesions remaining in the template DNA.
In this scenario, cells employ damage bypass mechanisms to complete genome replication and prevent fork breakage.
Importantly, these pathways are not…
UNIVERSIDAD DE SEVILLA
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