CORDIS Project
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This project investigates DNA demethylation, a key process in gene regulation, particularly focusing on the role of the Gadd45 protein in this mechanism. It aims to explore its biological significance during development and in adult organisms, using mouse models to uncover the underlying molecular interactions.
Epigenetic gene regulation is of central importance for development and disease.
Despite dramatic progress in epigenetics during the past decade, DNA demethylation remains one of the last big frontiers and very little is known about it. DNA demethylation is a widespread phenomenon and occurs in plants as well as in animals, during development, in the adult, and during somatic cell reprogramming of pluripotency genes.
The molecular identity of the DNA demethylase in animal cells remained unresolv…
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH
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Germany, Heidelberg
Type: Research institute
Activity type: Research Organisations
SME: No
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