CORDIS Project
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This project explores DNA-encoded selection methods to discover small molecules that bind to specific proteins. By using unique DNA barcodes, it aims to enhance the identification of potential drug candidates through high-throughput screening techniques.
DNA-encoded based selection methods represent a novel avenue for the facile discovery of binding molecules from large libraries.
Unique DNA fragments covalently attached to small molecules serve as amplifiable identification barcodes.
The encoding allows the in vitro selection of ligands at sub‐picomolar concentrations from large library populations by affinity capture on a target protein of interest, in analogy to established technologies for the selection of binding polypeptides (e.g., antibod…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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