CORDIS Project
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This project investigates the roles of DNA metabolism genes in chromosomal replication using a cell-free extract from frog eggs. By employing advanced imaging and proteomic techniques, it aims to elucidate the mechanisms behind DNA replication and repair in vertebrates, enhancing our understanding of genome stability.
Faithful chromosomal DNA replication is essential to maintain genome stability. A number of DNA metabolism genes are involved at different levels in DNA replication.
These factors are thought to facilitate the establishment of replication origins, assist the replication of chromatin regions with repetitive DNA, coordinate the repair of DNA molecules resulting from aberrant DNA replication events or protect replication forks in the presence of DNA lesions that impair their progression.
Some DNA m…
UNIVERSITA DEGLI STUDI DI MILANO
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