CORDIS Project
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This project investigates the role of DNA methylation changes at enhancer regions in B-cell differentiation and malignancies, particularly mantle cell lymphoma. By analyzing chromosomal structures and gene expression, it aims to uncover the molecular mechanisms underlying these cancers.
B-cell differentiation is a complex process in which epigenetic changes, i.e., DNA methylation and histone modifications, play an essential role to regulate gene expression.
Disturbances in epigenetic processes can result in development of B-cell malignancies, such as mantle cell lymphoma (MCL).
So far, little is known about the epigenetic alterations underlying MCL.
In general, epigenetic studies in cancer have mainly dealt with identification of hypermethylated promoter regions.
Recent genome-…
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
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