CORDIS Project
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This project investigates the maintenance of DNA hydroxymethylation and methylation patterns during cell division. By developing new technologies, it aims to understand how these epigenetic marks are propagated and their implications for cell identity and disease.
BackgroundDNA hydroxymethylation and methylation are marks on DNA that help define cell identity and maintain genome stability. DNA hydroxymethylation is recently discovered, and the mechanisms underlying its maintenance are uncharacterised. DNA methylation is crucial for cell function, but large blocks of DNA lose methylation in cancerous and ageing cells.
It has been speculated that this is due to aberrant maintenance during cell division, however, technical limitations have prevented this fro…
KOBENHAVNS UNIVERSITET
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