CORDIS Project
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This project investigates the cellular responses to DNA-protein crosslinks, which can lead to mutations and diseases like cancer. By using a new cell-based system, the project aims to identify and characterize factors involved in repairing these crosslinks, enhancing our understanding of genome stability.
DNA damage can cause mutations and genome instability and is therefore the underlying cause of many pathologies including neurodegeneration and cancer.
To maintain genome integrity, cells are equipped with sophisticated pathways for efficient repair of the broad spectrum of lesions that frequently arise in cellular DNA.
By now, most DNA repair pathways are well understood.
However, dedicated mechanisms for the repair of DNA-protein crosslinks (DPCs) have only been discovered very recently and ar…
KOBENHAVNS UNIVERSITET
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