CORDIS Project
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This project investigates DNA repair mechanisms to understand genetic predispositions to diseases like breast cancer and Ataxia with Oculomotor Apraxia-1. It focuses on the interactions between specific cancer syndromes and the roles of key proteins in DNA repair processes.
Our genetic material is continually subjected to damage, either from endogenous sources such as reactive oxygen species produced as by-products of oxidative metabolism, from the breakdown of replication forks during cell growth, or by agents in the environment such as ionising radiation or carcinogenic chemicals.
To cope with DNA damage, cells employ elaborate and effective repair processes that specifically recognise a wide variety of lesions in DNA.
These repair systems are essential for the m…
THE FRANCIS CRICK INSTITUTE LIMITED
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