CORDIS Project
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This project focuses on developing a molecular crane using the flavoprotein dodecin to manipulate single molecules. By linking flavins to an atomic force microscope tip, the project aims to create a system that can pick up and release molecular objects through electric potential changes.
The flavoprotein dodecin from the halophilic organism Halobacterium salinarum binds not only native but also artificial flavins with high affinities in their oxidized state.
Reduction of the flavins induces the dissociation of the holocomplex into apododecin and free flavin.
Based on these unique binding characteristics, a molecular crane shall be developed that is able to pick up and to release molecular objects through a switch of the electric potential.
For this purpose, a single flavin has t…
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