CORDIS Project
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This project investigates how DNA sequences influence chromatin remodeling, which is crucial for gene regulation and DNA repair. By developing a high-throughput platform that combines single-molecule measurements with sequencing, the project aims to reveal the mechanisms behind nucleosome positioning and its impact on…
Eukaryotic genomes are packaged into chromatin, which restricts access to the DNA.
Key genomic processes therefore involve the rearrangement of chromatin by ATP-dependent chromatin remodelling enzymes (remodellers), which actively place and reorganise nucleosomes.
The precise positioning of nucleosomes plays a crucial role in regulating transcription, replication, and DNA repair. DNA sequence impacts this nucleosome architecture by affecting the activity of remodellers.
However, what mechanisms…
UPPSALA UNIVERSITET
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