CORDIS Project
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This project investigates the balance between stability and plasticity in neuronal circuits, particularly in relation to Alzheimer's disease. It aims to identify mechanisms that stabilize hippocampal activity and how disruptions in these mechanisms contribute to cognitive decline, using various experimental techniques.
Neuronal circuits must balance stability and plasticity.
How this balance is compromised in brain disorders remains one of the most fundamental questions in neuroscience.
Pioneering studies in the field established that homeostatic mechanisms stabilize the function of a system at a set-point level of activity.
Recently, we have identified bona fide mitochondrial regulator of activity set points and provided support to our standing hypothesis that homeostatic failures destabilize network activity…
TEL AVIV UNIVERSITY
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