CORDIS Project
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This project investigates how the amount of gene expression influences cellular and physiological functions, particularly in blood cells. By analyzing large genetic datasets and employing advanced experimental techniques, it aims to clarify the relationship between gene dosage and its impact on human traits and disease…
The expression dosage of a gene is a fundamental determinant of its downstream function at the cellular and organismal level, and its genetic or environmental perturbations are a driving force of most common and rare disease in humans.
However, we have limited understanding of the specific shape of dosage-to function-curves for human genes, what factors and mechanisms drive their variation across genes, phenotypes and cellular contexts, and how this contributes to functional architecture of huma…
KUNGLIGA TEKNISKA HOEGSKOLAN
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