CORDIS Project
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This project examines the evolution of dosage-sensitive genes that can lead to diseases when duplicated. By analyzing genomic data, it aims to identify genes that are crucial for maintaining cellular balance and their potential links to complex diseases.
Evolutionary change of gene copy number through gene duplication is a relatively pervasive phenomenon in eukaryotic genomes.
However, for a subset of genes such changes are deleterious because they result in imbalances in the cell.
Such dosage-sensitive genes have been increasingly implicated in disease, particularly through the association of copy number variants (CNVs) with pathogenicity.In my lab we have previously discovered that many genes in the human genome which were retained after whol…
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
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