CORDIS Project
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This project aims to develop new inhibitors for cholera toxin by creating dual-site ligands that mimic both the GM1 ganglioside and blood group antigens. These ligands will target distinct binding sites on the toxin, potentially leading to improved therapeutic strategies against cholera.
Specific binding between bacterial enterotoxins and oligosaccharides on the host cell membrane is a paradigm for protein-sugar interaction.
One of the best characterized recognition pairs is formed by ganglioside GM1 and the cholera toxin (CT).
Recently, Krengel´s group has identified a second binding site, which appears to be present in the close CT congener LT and in CT from the El Tor strain, responsible for the current cholera pandemic.
This binding site, which is clearly distinct from the…
UNIVERSITA DEGLI STUDI DI MILANO
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