CORDIS Project
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This project investigates the repair mechanisms of DNA-protein cross-links, which can lead to genomic instability. By developing an in vitro system, it aims to identify the factors involved in repairing these lesions during DNA replication.
DNA-protein cross-links (DPCs) are common DNA lesions caused by endogenous, environmental, and chemotherapeutic agents.
Cells are susceptible to these lesions during S phase, as DPCs impede replication fork progression and are likely to induce genomic instability, a cause of cancer and aging.
Despite its relevance to human health, the repair of DPCs is poorly understood.
Research on DPC repair has mainly involved testing cellular responses to compounds such as formaldehyde, but these agents indu…
KOBENHAVNS UNIVERSITET
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