CORDIS Project
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This project focuses on inhibiting Dipeptidyl-peptidase 9 (DPP9) to induce pyroptosis in acute myeloid leukemia cells. By utilizing targeted degradation technologies, it aims to enhance immune responses against cancer cells, potentially improving treatment strategies for leukemia and other cancers.
Dipeptidyl-peptidase 9 (DPP9) is a proline-selective serine protease that belongs to the peptidase S9 family.
During recent years, DPP9 inhibition has shown to cause pyroptosis, selectively in acute myeloid leukemia cells.
Pyroptosis is a lytic form of programmed cell death, that has mainly been observed in immune cells.
The process typically recruits and activates other immune cells and inflammatory mediators, causing a localized activation of the innate immune system.
This is particularly appe…
UNIVERSITEIT ANTWERPEN
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