CORDIS Project
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This project focuses on developing a vaccine targeting protein aggregation in neurodegenerative diseases, specifically for carriers of the C9orf72 gene mutation. It aims to create a comprehensive data package for rapid clinical development of the vaccine to prevent amyotrophic lateral sclerosis and frontotemporal demen…
Neurodegenerative diseases are triggered by protein aggregation in the CNS, but developing therapies has been challenging.
Since key disease mechanisms change during disease progression, halting further neuron loss has not been achieved and may not even improve the symptoms and survival.
Causal therapy is most realistic for monogenic disease variants.About 10% of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases are caused by repeat expansion in the C9orf72 gene.
We hav…
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
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