CORDIS Project
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This research focuses on the movement and regulation of small RNAs between cells, particularly in the mammary gland. It aims to understand how these RNA molecules are transferred and their potential roles in systemic gene silencing across different organisms.
Small RNAs are key post-transcriptional regulators of eukaryotic gene expression.
Among the most fascinating aspects of small RNAs is their ability to cross cell boundaries owing to their non-cell-autonomy.
Recently, the host laboratory demonstrated that 21-24bp siRNAs could act as mobile silencing signals in Arabidopsis.
Interestingly, in C.
Elegans, systemic silencing requires SID1, a transmembrane channel through which endogenous double-stranded RNA may be communicated to adjacent cells.
Func…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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