CORDIS Project
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This project focuses on developing new strategies to disrupt bacterial biofilms, particularly targeting the molecule cyclic-di-GMP to enhance antibiotic effectiveness against Pseudomonas aeruginosa. It employs advanced techniques like next generation sequencing and computational drug docking to identify potential drug…
Bacterial biofilms are closely associated with chronic infections, leading to much higher tolerance to antibiotics and treatment failures.
New strategies for biofilm disruption are thus urgently required.
Cyclic-di-GMP, a secondary messenger promoting biofilm formation, is a promising drug target.
Only few compounds that reduce c-di-GMP levels and inhibit biofilms were identified so far, and most studies were conducted in vitro using standard medium and reference strains.
In this project drugs w…
UNIVERSITEIT GENT
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