CORDIS Project
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This project investigates the mechanisms of neuronal degeneration caused by stress in the endoplasmic reticulum, using the fruit fly Drosophila melanogaster as a model. It aims to understand how misfolded proteins trigger cell death and the role of the Unfolded Protein Response in neuronal development.
The endoplasmic reticulum (ER) is the cell organelle where secretory and membrane proteins are synthesized and folded.
The presence of unfolded/misfolded proteins in the ER causes stress to the cell (“ER stress”) and activates the Unfolded Protein Response (UPR), a cellular response to restore homeostasis in the ER.
The presence of misfolded proteins and activation of the UPR have been connected with many diseases and pathological conditions.
My goal is to elucidate the molecular mechanisms that…
INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA
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