CORDIS Project
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This project investigates how cells choose between two repair pathways for double strand breaks in DNA, which is crucial for normal development and cancer treatment. Understanding this decision-making process may lead to new therapeutic strategies for cancer and genetic disorders linked to DNA repair deficiencies.
Double strand breaks (DSBs) repair is essential for normal development.
While the complete inability to repair DSBs leads to embryonic lethality and cell death, mutations that hamper this repair cause genetically inherited syndromes, with or without cancer predisposition.
The phenotypes associated with these syndromes are extremely varied, and can include growth and mental retardation, ataxia, skeletal abnormalities, immunodeficiency, premature aging, etc.
Moreover, DSBs play an extremely releva…
UNIVERSIDAD DE SEVILLA
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