CORDIS Project
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This project aims to develop a universal model for transcription initiation in cells by analyzing high-throughput data. It focuses on understanding how core promoters are selected and how DNA accessibility impacts gene regulation, which is crucial for future studies in molecular biology.
Understanding the mechanisms underlying the initiation and regulation of transcription remains one of the most fundamental questions in biology.
Much of what we know about the transcription process was inferred from experiments on a handful of genes.
As these experiments are not realistically scalable, corresponding computational methods building on these findings have emerged; however, these are not accurate enough for annotation of genomes.
The limitations reflect that we have no accurate univ…
KOBENHAVNS UNIVERSITET
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