CORDIS Project
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This project aims to create a novel system for large-scale functional screening of genomic enhancers using CRISPR/Cas9 technology. By developing a dual-guide RNA expression system, it seeks to identify essential enhancers that maintain mouse embryonic stem cell identity.
Enhancers are cis-regulatory genomic regions that can modulate gene expression in a cell type-specific and time-controlled manner to regulate cellular behaviour.
ChIP-seq and RNA-seq technologies have allowed genome-wide identification of potential enhancers based on the correlation among specific chromatin marks, transcription factor biding sites and gene expression.
However, strategies to validate their function are still limited.
Recently, it has been demonstrated that the CRISPR/Cas9 genome…
THE UNIVERSITY OF EDINBURGH
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