CORDIS Project
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This project investigates the interaction between the 26S Proteasome and the deubiquitinating enzyme USP9X, aiming to understand how this relationship affects their enzymatic functions. The research may lead to new drug targets for neurodegeneration and cancer treatments by revealing novel mechanisms in protein degrada…
Clearing-up old or redundant proteins is essential for cells to live; this job is largely done by 26S Proteasome.
The multisubunit complex – 26S Proteasome – is extraordinarily conserved throughout all eukaryotic phyla, in terms of subunit composition and overall structure.
However, in preparation of this research proposal, the Researcher found a novel association of 26S proteasome with a clinically important deubiquitinating enzyme (DUB), USP9X.
In a subset of proteasome purified from human tis…
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