CORDIS Project
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This project investigates the role of cofactors in the transcription process within living yeast cells. By utilizing advanced imaging techniques, it aims to understand how these cofactors influence transcription dynamics, providing insights into the molecular mechanisms that enhance transcription efficiency.
Transcription is a multi-step process involving many regulatory factors, including cofactors such as Mediator, chromatin remodelers and chromatin modifiers.
Cofactors are thought to enhance transcription efficiency, but a detailed mechanistic understanding of cofactor action is still lacking.
Inside single cells, the transcriptional process is highly dynamic, with regulatory factors transiently associating to DNA, and transcription occurring in stochastic bursts of high transcriptional activity,…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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