CORDIS Project
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This project investigates how protein complexes regulate genome duplication in living cells, focusing on the mechanisms that ensure accurate replication and the consequences of defects in these processes. It combines live cell imaging, genetic studies in fission yeast, and computational analysis to explore the implicat…
Accurate genome duplication is controlled by multi-subunit protein complexes which associate with chromatin and dictate when and where replication should take place.
Dynamic changes in these complexes lie at the heart of their ability to ensure the maintenance of genomic integrity.
Defects in origin bound complexes lead to re-replication of the genome across evolution, have been linked to DNA-replication stress and may predispose for gene amplification events.
Such genomic aberrations are centra…
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