CORDIS Project
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The DynaDiff project investigates how specific gene regulatory networks influence transcriptional dynamics during the differentiation of embryonic stem cells. By developing advanced sequencing methods, it aims to uncover the roles of membraneless organelles in gene regulation and chromatin organization, enhancing our u…
Development is driven by transcriptional programs where specific gene regulatory networks (GRN) control genes on several time scales.
However, the extent to which transcriptional dynamics are coordinated for different genes and how the differential downregulation of the progenitor GRN determines cell fate remains poorly understood.
This in part due to the difficulty of measuring genome-wide transcription with temporal resolution in complex developmental systems.
Plus, transcription occurs in the…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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