CORDIS Project
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This project investigates allostery in proteins, focusing on how distant sites influence activity through conformational changes. By using innovative techniques like ultrafast infrared spectroscopy, the project aims to map energy transfer pathways in proteins, enhancing our understanding of molecular communication.
Allostery is a fundamental concept Nature uses to regulate the affinity of a certain substrate to an active site of a protein by binding a ligand to a distant allosteric site.
We will design experimental tools to gain an atomistic understanding of the conformational transitions that give rise to allostery.
We will approach the problem from two distinctively different directions.
First, we will initiate conformational transitions of proteins that per se are not photoswitchable, by cross-linking t…
University of Zurich
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