CORDIS Project
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This project aims to understand the dynamics of transcription factor interactions with chromatin, focusing on their binding rates and effects on gene regulation. It seeks to uncover how these dynamics influence transcriptional outcomes across the genome.
Transcription is a stepwise process that is inherently dynamic.
Different types of transcription factors are continuously interacting off and onto DNA, ""searching"" for appropriate interactions - each bringing different functions into play.
The rates with which these factors interact with chromatin, their association and dissociation rates, dictate the outcome of ""steady-state"", developmental and rapidly responsive regulatory programs.
Given the central role of transcription factors in biolog…
PrinsesMaximaCentrumvoorKinderoncologie
PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
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