CORDIS Project
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This project investigates the role of DNA methylation in early embryonic development, focusing on its non-traditional functions in gene activation. Using both cell-based systems and mouse models, it aims to understand how DNA methylation impacts gene expression and development.
Immediately after fertilization, mammalian genomes undergo a dramatic reshaping of the epigenome as the embryo transitions from the zygote into the pluripotent cells primed for lineage commitment.
This is best exemplified by DNA methylation reprogramming, as the gametic patterns are largely erased, and the embryonic genome undergoes a wave of de novo DNA methylation.
Moreover, once DNA methylation patterns are established, mechanisms faithfully maintain the mark across cell division.
Thus, there…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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