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The DynamHet project investigates the diverse roles of cancer-associated fibroblasts (CAFs) in tumor development, focusing on their heterogeneity and plasticity. By analyzing CAF subtypes and their interactions within the tumor microenvironment, the project aims to develop strategies for reprogramming CAFs to enhance c…
Cancer-associated fibroblasts (CAFs) are one of the most abundant and versatile cell types in the tumour microenvironment (TME), where they crosstalk with stromal cells and actively participate in tumour development.
Because of their assumed pro-tumourigenic functions, CAFs have long been considered an attractive therapeutic target.
However, recent evidence indicates that multiple CAF subpopulations showing inflammatory, myofibroblastic, vascular, antigen-presenting, and immunosuppressive phenot…
FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
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