CORDIS Project
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The project aims to uncover mechanisms of rare neurodegenerative diseases using human induced pluripotent stem cells and advanced spatial proteomics. By mapping protein localization changes in affected neurons, it seeks to enhance understanding of disease processes and identify potential therapeutic targets.
Rare diseases are a major unmet medical need, as is the definition of the relevant disease mechanisms.
Many rare diseases affect the nervous system.
These are challenging to treat, and mechanistic studies are difficult due to the inaccessibility of patient tissue.
Global proteomic studies have provided insight into whole tissue or cell changes in protein abundance but lose information on protein subcellular localisation, which is important because defects in protein trafficking are implicated in…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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