CORDIS Project
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This project investigates the role of microtubules in synaptic plasticity, focusing on their dynamic behavior within dendritic spines. By combining various techniques, it aims to understand how microtubule entry affects spine structure and function, contributing to learning and memory.
Synaptic connections within the adult brain are not fixed and stable but remarkably flexible.
This reorganisation of synaptic connectivity is a basic principle of neuronal plasticity and believed to represent the cellular basis for learning and memory function.
Dendritic spines form the dynamic postsynaptic component of most excitatory synapses in the brain.
Recent studies from the host laboratory revealed the invasion of microtubules (MT) into dendritic spines.
Several lines of evidence indicat…
UNIVERSITEIT UTRECHT
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