CORDIS Project
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This project explores how cells integrate signals from multiple genetic circuits to control cellular processes. It combines modeling and time-lapse microscopy to study dynamic signal encoding strategies and the effects of noise on gene regulation in two model systems: Bacillus subtilis and Cyanobacteria.
Cells must integrate output from multiple genetic circuits in order to correctly control cellular processes.
Despite much work characterizing regulation in these circuits, how circuits interact to control global cellular programs remains unclear.
This is particularly true given that recent research at the single cell level has revealed that genetic circuits often generate variable or stochastic regulation dynamics.
In this proposal we will use a multi-disciplinary approach, combining modelling a…
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