CORDIS Project
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This project investigates how autoantibodies against NMDA glutamate receptors affect their membrane dynamics and interactions in neurons. By analyzing these changes, the research aims to understand their role in neuropsychiatric disorders and neuronal excitability.
NMDA glutamate receptors (NMDAR) are undisputed key players in synaptic plasticity, a role that has been attributed to their calcium permeability.
It emerged over the past decade that the membrane trafficking and nanoscale organization of NMDARs also plays a major role in synaptic adaptation.
This was further substantiated by the discovery that patients autoantibodies targeting NMDARs (NMDAR-Abs) induce major psychiatric and neurological symptoms through compromised NMDAR surface trafficking but…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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France, Bordeaux
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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