CORDIS Project
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This project aims to enhance the understanding of bone formation by combining liquid-phase electron microscopy with immunolabelling techniques. It focuses on visualizing the interactions between collagen, hydroxyapatite, and regulatory proteins during mineralization, providing real-time insights into the complex bioche…
Bone is a complex nanocomposite with outstanding mechanical properties arising from the nanoscale interaction between its two main building blocks: type I collagen fibrils and hydroxyapatite crystals.
Despite its clinical relevance, the mechanisms governing bone formation are still poorly understood, mainly due to the complexity of the processes.
During bone formation and remodeling, non-collagenous proteins and proteoglycans act synergistically to regulate the mineral deposition process, partic…
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
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