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The DynaMitE project investigates how gene regulatory sequences interact during the transition from mitosis to interphase in live cells. By using advanced imaging and genome engineering techniques, it aims to uncover the mechanisms that restore gene expression and maintain cell identity after cell division.
In spite of intense investigations, it remains unclear whether and how the interaction between promoters and distant enhancers has an instructive role in transcription. I will tackle this question by tracking the spatial and temporal dynamics of gene regulatory sequences alongside nascent transcription during the critical biological event that is the mitosis-to-interphase transition in live cells.
During mitosis, chromatin undergoes a massive reorganization, resulting in the loss of long-range i…
INSTITUT PASTEUR
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